Introducing Kyzatrex: A safe, effective and painless option for Testosterone Replacement Therapy

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August 14, 2023 | 4 minute read

Are you looking for a safe, effective, and painless option for Testosterone Replacement Therapy? We are now offering Kyzatrex™ (testosterone undecanoate), an innovative oral testosterone capsule indicated for testosterone replacement therapy in adult males for conditions associated with a deficiency or absence of endogenous testosterone.

Who is Affected by Low Testosterone?

Male hypogonadism is a medical condition that can impact men of all ages, though it is more prevalent among those:

  • Who are older
  • Who have Type 2 diabetes
  • Are obese
  • With chronic medical conditions
  • With HIV/AIDS
  • With obstructive sleep apnea

Low testosterone affects ~15 million men of ages 25-75 in the US alone, 40% of men older than 45 years old, 30-50% of men with type 2 diabetes1, and approximately half of men who are overweight. Additionally, more than 66% of men suffering from erectile dysfunction have low testosterone levels.

Causes and Symptoms Low Testosterone:

Low testosterone is caused by your testicles not producing adequate levels of testosterone. It is more common in older men as testosterone levels drop 1-2% per year beginning in your 40s. As testosterone levels decline, some potential symptoms include impotence, anxiety, weight gain, anemia, lower vitality, and reduced muscle mass. Moreover, men with low testosterone are 4x more likely to be diagnosed with clinical depression, and low testosterone can also cause osteoporosis in older men.

Current TRT Landscape:

Currently, there are four major types of TRT solutions other than oral testosterone pills (what Kyzatrex™ is): injections, implanted pellets, gels, and patches.

The most common form of TRT is injections. While these treatments are readily available, they are difficult and painful to use2. Additionally, some side effects of TRT injections include allergic reactions such as rashes, itching, hives, swelling, blood clots, mood swings, sleep apnea, worsening mood, and depression, along with more serious effects such as heart attacks, liver injury, and strokes3.

Another form of TRT is implanted pellets, however these require a medical professional to insert which is both time consuming and can cause pain4. Additional side effects of implanted pellets include swelling at the implantation site, nausea and vomiting, acne, changes in body hair, and cardiovascular risks5.

Next, there are testosterone gels. While these do have the benefit of being painless, they add the additional inconvenience of being messy to use6. Additionally, topical gels could potentially have harmful effects on others who touch your skin (especially women and children), acne, depression, headaches, mood changes, skin irritation, leg pain, shortness of breath, a decrease in the number of sperm cells produced, and prostate cancer7.

Finally, we have testosterone patches which have the immediate downsides of taking longer to use and also being visible on your body8. Additional side effects include blood clots, diabetes, drug abuse, sleep apnea, strokes, prostate cancer, organ disease, and sleep apnea9.

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Why Kyzatrex™ is a Better and Safer Alternative:

Kyzatrex™ is revolutionizing the testosterone replacement therapy industry by providing an alternative treatment that is easy to swallow, invisible (unlike testosterone patches), leaves no mess (unlike testosterone gels), is painless (unlike both testosterone injections and implanted pellets), and has flexible dosing10.

Kyzatrex™ is an FDA-approved drug that has been thoroughly clinically tested and found to have a 96% success rate in restoring men with low testosterone levels to normal testosterone levels at the end of a 90-day study. Additionally, each Kyzatrex™ oral testosterone pill has been uniquely formulated to be easily absorbed through the lymphatic system and bypass your liver which makes the delivery process efficient without causing liver toxicity as shown in Phase 3 trials11.

Finally, Kyatrex™ is easy to use with daily oral dosing. Just two oral doses per day of Kyzatrex™ with food can restore your testosterone levels to normal and keep them there. Moreover, everybody is different so Kyzatrex™ has flexible dosing at 100mg, 150mg, and 200mg capsule sizes which can be adjusted by your doctor as needed after starting your treatment.

Side Effects for Kyzatrex:

As with all drugs, Kyzatrex™ does have potential side effects, however. During clinical trials, the only side effect found in >2% of patients was high blood pressure at 2.6%. Other side effects were found in <2% of patients. Additionally, in this study of 155 patients over six months, only one patient discontinued due to a side effect and this was simply acne12.

Next Steps:

Want to start Kyzatrex™? Contact our clinicians to get your testosterone levels checked and increase your energy levels, sexual drive, and overall mood soon!


KYZATREX™ (testosterone undecanoate) is a prescription drug that is used to treat adult men who have low or no testosterone levels due to certain medical conditions.

KYZATREX™ is a controlled substance (CIII) because it contains testosterone. It is not known if KYZATREX™ is safe or effective in males younger than 18 years old. Improper use may affect bone growth in children. KYZATREX™ is not meant for use by women.

Important Safety Information for KYZATREX™

KYZATREX™ can increase blood pressure, which can increase the risk of having a heart attack or stroke and can increase risk of death due to a heart attack or stroke. Your risk may be greater if you have already had a heart attack or stroke or if you have other risk factors for heart attack or stroke.

  • If your blood pressure increases while on KYZATREX™, blood pressure medicines may need to be started. If you are currently taking blood pressure medicines, they may need to be changed or new blood pressure medicines may need to be added to control your blood pressure.
  • If your blood pressure cannot be controlled, KYZATREX™ may need to be stopped.
  • Your healthcare provider will monitor your blood pressure while you are being treated with KYZATREX™.

Do not take KYZATREX™ if you: have breast cancer; have or might have prostate cancer; are a woman who is pregnant (KYZATREX™ may harm your unborn baby); are allergic to KYZATREX™ or any of its ingredients; or have low testosterone without certain medical conditions (e.g., do not take KYZATREX™ if you have low testosterone due to age).

Before you take KYZATREX™, tell your healthcare provider about all of your medical conditions, including if you: have high blood pressure or are treated for high blood pressure; have a history of diabetes; have heart problems; have high red blood cell count (hematocrit) or high hemoglobin laboratory value; have urinary problems due to an enlarged prostate; have liver or kidney problems; or have problems breathing while you sleep (sleep apnea).

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking KYZATREX™ with certain other medicines can affect each other. Especially, tell your healthcare provider if you take: insulin; medicines that decrease blood clotting (blood thinners); corticosteroids; or medicines that increase blood pressure, such as some cold medicine and pain medicines.

KYZATREX™ may cause other serious side effects including:

  • Increase in red blood cell count (hematocrit) or hemoglobin, which can increase the risk of blood clots, strokes, and heart attacks. You may need to stop KYZATREX™ if your red blood cell count increases.
  • If you already have an enlarged prostate, your signs and symptoms may worsen while taking KYZATREX™. These may include: increased urination at night; trouble starting your urine stream; urinating many times during the day; urge to go to the bathroom right away; a urine accident; inability to pass urine or weak urine flow.
  • Increased risk of prostate cancer.
  • Blood clots in the legs or lungs. Signs and symptoms of a blood clot in your leg can include pain, swelling or redness. Signs and symptoms of a blood clot in your lungs can include difficulty breathing or chest pain.
  • Abuse. Testosterone can be abused when taken at higher than prescribed doses and when used with other anabolic androgenic steroids. Abuse can cause serious heart and psychological side effects.
  • In large doses, KYZATREX™ may lower your sperm count.
  • Liver problems. Symptoms of liver problems may include: nausea or vomiting; yellowing of your skin or whites of your eyes; dark urine; pain on the right side of your stomach area (abdominal pain).
  • Swelling of your ankles, feet, or body (edema), with or without heart failure.
  • Enlarged or painful breasts.
  • Breathing problems while you sleep (sleep apnea).

Call your healthcare provider right away if you have any of the serious side effects listed above.

The most common side effect of KYZATREX™ is high blood pressure. Other side effects may include: headache, joint or back pain, diarrhea, increased red blood cell count, anxiety, constipation, swelling of the legs, and increased prostate specific antigen (PSA) levels.

These are not all the possible side effects of KYZATREX™. For more information, ask your healthcare provider or pharmacist.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088. You may also report side effects to Marius [by visiting].

Keep KYZATREX™ and all medicines out of the reach of children.

See Full Prescribing Information and Medication Guide for KYZATREX™.

EUTHYROX®, a branded
Levothyroxine is also available.

Tap here to know more

Buying Kyzatrex for the first time?

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